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MODIFIED ADENO-ASSOCIATED VIRUS VECTORS THAT EVADE NEUTRALIZING ANTIBODIES AND USES THEREOF
MODIFIED ADENO-ASSOCIATED VIRUS VECTORS THAT EVADE NEUTRALIZING ANTIBODIES AND USES THEREOF
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机译:修改的腺相关病毒载体逃避中和抗体及其用途
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摘要
The present invention is in the field of recombinant adeno-associated virus (AAV) vectors. In particular, the invention relates to AAV vectors comprising modified AAV capsid proteins that evade neutralizing antibodies but are still able to transduce hepatocytes. The invention further relates to methods of using the AAV vectors to deliver products to subjects and treat diseases.
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