METHOD FOR OBTAINING NON-TOXIC GELS BASED ON MODIFIED CARBOXYMETHYLCELLULOSE AND THEIR USE IN MEDICINE

摘要

FIELD: medicine. ;SUBSTANCE: group of inventions relates to the field of medicine, namely to a gel based on modified carboxymethylcellulose or its pharmaceutically acceptable salt for use as a filler for medical implants, a carrier substance, a lubricant and/or an anti-adhesion barrier, an anti-adhesive gel or an intradermal filler and to a method for producing a gel based on modified carboxymethylcellulose or its pharmaceutically acceptable salt, including the following stages: a) the creation of covalent bonds between the molecules of carboxymethylcellulose or its pharmaceutically acceptable salt by interacting in solution with carboxymethylcellulose or its pharmaceutically acceptable salt with a crosslinking agent, which is a substituted oxyrane selected from 1,4-butanedioldiglycidyl ether, polyethylene glycoldiglycidyl ether or polypropylene glycoldiglycidyl ether; b) neutralization of free epoxy groups in modified carboxymethylcellulose or its pharmacologically acceptable salt obtained at stage a), and neutralization of the crosslinking agent residues by adding an amino acid or a combination of at least two amino acids to the reaction mixture obtained at stage a); c) removal of the amino acid and/or crosslinking agent residues by dialysis of the gel obtained after stage b) in a sodium-phosphate physiological buffer solution or water for injection. ;EFFECT: group of inventions provides for the development of a new effective method for producing a gel by modifying carboxymethylcellulose or its pharmacologically acceptable salt, which has low toxicity, and this method for production is well scalable and makes it possible to obtain low-toxic and biocompatible gels with a high degree of purity. ;22 cl, 9 dwg, 2 tbl, 15 ex