PHARMACEUTICAL COMPOSITION CONTAINING OMEGA-3 FATTY ACID AND A STATIN HYDROXY-DERIVATIVE, AND METHODS OF USING IT

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: group of inventions relates to the treatment of cardiovascular diseases. Pharmaceutical composition for oral administration to reduce hydroperoxides of lipids in cell membranes contains 2.5–100 mg of a hydroxy-derivative of atorvastatin or a pharmaceutically acceptable salt thereof and an oil comprising omega-3 fatty acid, wherein the omega-3 fatty acid contains at least 95 wt % ethyl eicosapentaenoate from all fatty acids present or at least 95 wt % ethyl docosahexaenoate from all fatty acids present. Also disclosed are a capsule for reducing hydroperoxides of lipids in cell membranes and a method of reducing hydroperoxides of lipids in cell membranes in a subject.;EFFECT: group of inventions provides low formation of lipid peroxides in cell membranes.;14 cl, 9 dwg, 1 ex