COMPOSITIONS AND METHODS FOR EXPRESSING SEVERAL BIOLOGICALLY ACTIVE POLYPEPTIDES FROM ONE VECTOR FOR THE TREATMENT OF HEART DISEASES AND OTHER PATHOLOGIES

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to the field of biotechnology, specifically to polynucleotide for the expression of functional calcium-binding protein S100A1, stromal cell-derived factor-1α (hereinafter – SDF-1α) and vascular endothelial growth factor 165 (hereinafter – VEGF165); it can be used in medicine.;EFFECT: obtained polynucleotide allows for simultaneous expression of S100A1, SDF-1α and VEGF165; it can be used for the effective treatment of heart diseases.;19 cl, 33 dwg, 16 tbl, 14 ex