COMPOSITION FOR USE IN PREVENTION OR TREATMENT OF OESOPHAGEAL DISEASES LINKED TO EPITHELIAL BARRIER DEFECTS

摘要

A composition comprising quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one) and/or myricetin (3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one) is used in the prevention or treatment of heartburn, gastroesophageal reflux disease (GERD) or Eosinophilic Esophagitis (EoE). The composition reinforces tight junction strength in the oesophagus wall at low concentrations, restoring healthy barrier function to the oesophagus and resistance to acid. The composition prevents acid from penetrating the oesophagus, irritating underlying nerves and causing pain.