DIBORIDE MICROPATTERNED SURFACES FOR CELL CULTURE

摘要

The present disclosure relates to a micropatterned substrate that combines Si and TiB2, promoting preferential and selective cell growth behavior via substrate-mediated protein adsorption. The combination of Si and TiB2, differing in material stiffness, hardness, roughness, wettability and surface charges, is amenable to microfabrication processes and supports extended 2D and 3D cell culture. While versatile in the variety of customizable geometric patterns, the micropatterned substrate is a particularly appropriate platform for viable tissue culture.