METHOD FOR DIFFERENTIAL DIAGNOSTICS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS ASSOCIATED WITH HUMAN PAPILLOMA VIRUS OF HIGH ONCOGENIC RISK

摘要

FIELD: medicine.;SUBSTANCE: invention relates to the field of medicine, in particular, to gynecology, and is intended for differential diagnostics of cervical intraepithelial neoplasias associated with human papilloma virus of high oncogenic risk. The amount of cells with the CD3+CD4+PD1+TIM3+ and CD3+CD4+PD1+LAG3+ phenotype in the general population of CD3+CD4+ T-lymphocytes is determined in an immunological study. If the amount of cells with said phenotype in each of the variants is less than 2% of the total population of CD3+CD4+ T-lymphocytes, I degree cervical intraepithelial neoplasia is diagnosed. If the amount of cells with said phenotype in each of the variants is 2 to 5% in the total population of CD3+CD4+ T-lymphocytes, II degree cervical intraepithelial neoplasia is diagnosed. If the amount of cells with said phenotype in each of said cases is greater than 5%, III degree cervical intraepithelial neoplasia is diagnosed. ;EFFECT: invention ensures determination and differentiation of the degree of development of cervical intraepithelial neoplasia and a reduction in the duration of stay of patients in the in-patient facility.;1 cl, 4 ex