Spiropiperidin-based nicotinic acetylcholine receptor allosteric regulator

摘要

The present disclosure discloses compounds of formula I useful as regulators of 7nAChR, compositions containing such compounds, and the central nervous system such as cognitive dysfunction in diseases, especially Alzheimer''s disease, Parkinson''s disease, and schizophrenia. And the use of such compounds to prevent, treat or ameliorate L-DOPA-induced movement disorders and inflammation. (I). [Chemical 1]