Novel compounds useful as near infrared fluorescent probes selectively binding to tau aggregates and preparation method thereof

摘要

The present invention relates to a compound having near-infrared fluorescence selectively binding to tau aggregates and a method for preparing the same, a tau-targeted near-infrared fluorescent probe comprising the compound, a composition for detecting tau fiber protein comprising the near-infrared fluorescent probe as an active ingredient, and to the use of the composition for diagnosing tauopathy. In particular, since the compound of the present invention does not bind to amyloid beta protein and has high selectivity for tau aggregates specifically reported as the etiology of the initial state of tauopathy, tau fibers for early diagnosis of tauopathy including Alzheimer's disease It can be usefully utilized as a near-infrared fluorescence detector for protein detection.