a5 Composition for preventing treating or improving neurodegenerative diseases comprising Euchrenone a5

摘要

The present invention relates to a composition for preventing, treating, or ameliorating neurodegenerative diseases, including euchrenone a 5 (euchrenone a 5), wherein euchrenone a 5 according to the present invention is IFN-γ induced in microglia. Inhibits IL-6, TNF-α, IP-10, ICAM-1 and MCP-1 production, and also inhibits iNOS, COX-2 protein expression, and phosphorylation of JAK2 and STAT1. Therefore, euchrenone a 5 is expected to be usefully used for the prevention, treatment, or improvement of IFN-γ-related neurodegenerative diseases.