METHODS OF ENHANCING PROTECTION AGAINST ORGAN AND VASCULAR INJURY, HEMATOPOIETIC RECOVERY AND SURVIVAL IN RESPONSE TO TOTAL BODY RADIATION/CHEMICAL EXPOSURE

摘要

Methods of mitigating vascular injury, promoting organ and hematopoietic recovery, accelerating vascular recovery, and enhancing survival in a subject treated with radiation therapy or chemotherapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088, is used at the appropriate times relative to the Total Body Irradiation or Chemotherapy exposure to achieve these prophylactic and/or therapeutic benefits.