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Human growth hormone fusion protein with enhanced thermal stability and cosmetic composition for anti-wrinkle and maintaining skin elasticity comprising the same as effective component
Human growth hormone fusion protein with enhanced thermal stability and cosmetic composition for anti-wrinkle and maintaining skin elasticity comprising the same as effective component
A human growth hormone fusion protein has enhanced thermal stability. The human growth hormone fusion protein has the amino acid sequence SEQ ID NO: 3 or SEQ ID NO: 4. A gene encoding the human growth hormone fusion protein has E. coli codon-optimized nucleotide sequence of SEQ ID NO: 5 or SEQ ID NO: 6. A recombinant vector includes the aforementioned gene. A host cell is transformed with the aforementioned recombinant vector. A method for producing in a host cell a human growth hormone fusion protein includes transforming a host cell with the aforementioned recombinant vector. The human growth hormone fusion protein may improve skin wrinkle and maintain skin elasticity. As the human growth hormone fusion protein has thermal stability and also has an effect of improving skin wrinkle and increasing the effect of maintaining skin elasticity, it can be advantageously used as a raw material of cosmetics.
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机译:人生长激素融合蛋白具有增强的热稳定性。 人生长激素融合蛋白具有氨基酸序列SEQ ID NO:3或SEQ ID NO:4。编码人生长激素融合蛋白的基因具有大肠杆菌密码子优化的SEQ ID NO:5或SEQ ID的核苷酸序列 不:6。重组载体包括上述基因。 用上述重组载体转化宿主细胞。 在宿主细胞中生产的方法A人生长激素融合蛋白包括用上述重组载体转化宿主细胞。 人生长激素融合蛋白可以改善皮肤皱纹并保持皮肤弹性。 随着人体生长激素融合蛋白具有热稳定性并且还具有改善皮肤皱纹并增加保持皮肤弹性的效果的效果,它可以有利地用作化妆品的原料。
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