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COMPOSITIONS AND METHODS FOR USING TRANSPLANTED MICROGLIA AS A VEHICLE FOR WIDESPREAD DELIVERY OF CELLS AND OTHER BIOLOGIC AGENTS TO THE BRAIN
COMPOSITIONS AND METHODS FOR USING TRANSPLANTED MICROGLIA AS A VEHICLE FOR WIDESPREAD DELIVERY OF CELLS AND OTHER BIOLOGIC AGENTS TO THE BRAIN
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机译:用于使用移植的微胶质细胞作为载体的组合物和方法,以广泛递送细胞和其他生物剂到大脑
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摘要
A method of replacing endogenous microglia of a subject's brain, e.g., an adult subject, with transplanted donor microglia includes depleting at least a portion of the endogenous microglia by administering to the subject a Colony Stimulating Factor 1 Receptor (CSFR1) inhibitor, wherein the CSFR1 inhibitor is blood-brain barrier permeable and pharmacologically ablates endogenous microglia; optionally stopping administration of the CSFR1 inhibitor for a time sufficient to prevent ablation of the transplanted donor microglia; and transplanting the donor microglia into the brain of the subject to provide the transplanted donor microglia.
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