NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES

摘要

The present patent application discloses naphthalimide derivatives and in particular e.g. N-aryl-substituted naphthalimidopropylamine derivatives (i.e. 2-[3-(amino)propyl]-1H-benz[de]isoquinoline-1,3(2H)- dione derivatives) such as e.g. such as e.g.(Formula I) or (Formula III) as anti-parasitic agents for the treatment of Leishmaniasis. The compounds could also be useful to treat viral, bacterial and/or neoplastic diseases. The description discloses exemplary synthesis as well as biological tests against Leishmania Infantum parasites (e.g. pages 54 to 58; examples 1 to 7). Exemplary compounds are:(example 3)(example 4) 2-(3-((5-amino naphtha lene-l-yl)amino)propyl)-lH-benzo[de]isoq uinoline-1, 3(2 H)-dione (example 5) 2-(3-((5-amino naphtha lene-l-yl)amino)propyl)-lH-benzo[de]isoq uinoline-1, 3(2 H)-dione (example 6)