METHOD OF PRODUCING MODIFIED AMYLOID PRECURSOR PROTEIN ANCHORED WITH DETECTABLE MOIETIES AND MODIFIED AMYLOID PEPTIDES DERIVED THEREOF

摘要

A method of ameliorating a disorder of insulin sensitivity, which entails administering an amount of one or more glucocorticoid receptor antagonists effective to ameliorate the disorder with no more than an acceptable activation of the hypothalamic-pituitary-adrenal axis, such that 24 hour serum or urine cortisol levels do not exceed about two to three times the upper normal limit, respectively.