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METHODS FOR SELECTIVELY INHIBITING MOLECULAR CHAPERONE CLIENTS AND COMPOSITIONS FOR USE THEREOF
METHODS FOR SELECTIVELY INHIBITING MOLECULAR CHAPERONE CLIENTS AND COMPOSITIONS FOR USE THEREOF
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机译:选择性地抑制用于使用的分子伴侣客户的方法及其用组合物
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摘要
The present disclosure relates to a method of identifying an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex, the method including: determining a three-dimensional (3D) structure of a client protein-of-interest; evaluating the 3D structure of the client protein-of-interest to identify an unstable substructure of the 3D structure of the client protein-of-interest; and determining an amino acid sequence of the unstable substructure of the 3D structure of the client protein-of-interest to identify an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex.
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