Lipid nanoparticle complex captured by cell permeable fused aptide (aptide) and its application

摘要

The present invention relates to a lipid nanoparticle complex in which an aptide fused with a cell permeable substance is collected and its use.Specifically, the lipid nanoparticle complex according to the present invention contains long and short chain phospholipids, while the lipid nanoparticle complex is discoid when long and short chain phospholipids are contained in a specific molar ratio while collecting the apices fused with the cell permeable substance Structure.AndWhen the apiptide for the STAT protein is captured as an aptide of the lipid nanoparticle complexCompared to the case of aptideExcellent for cell or skin cell permeabilityThe effect of psoriasis is shown without the side effect.TGF β By inhibiting expression of increased fibrosis related genes byLipid nanoparticle complex according to the present inventionIt can be used as a transmitter of various aptides.