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TRANSDERMAL ABSORPTION PREPARATION CONTAINING STABILIZED DONEPEZIL

机译:含有稳定的多奈哌齐的透皮吸收制剂

摘要

The present invention relates to a percutaneous absorption preparation comprising donepezil for the treatment of dementia. More specifically, the present invention relates to a percutaneous absorption preparation for the treatment of dementia comprising a support layer, a drug-containing layer, and a release layer, wherein the drug-containing layer comprises donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; monothioglycerol, thiocyanate metal salt (preferably potassium salt) or dimethylthiourea as a stabilizer; and a pressure-sensitive adhesive.;The present invention provides a percutaneous absorption preparation for the treatment of dementia with reduced the formation of donepezil impurities.
机译:本发明涉及一种经皮吸收剂,其包含多奈哌齐用于治疗痴呆。 更具体地,本发明涉及用于治疗痴呆的经皮吸收制剂,其包含载体层,含药层和剥离层,其中含药物的层包含多奈哌齐或其药学上可接受的盐作为活性物质 成分; 一分钟甘油,硫氰酸盐金属盐(优选钾盐)或二甲基硫脲作为稳定剂; 和压敏粘合剂。;本发明提供了一种经皮吸收剂,用于治疗痴呆,随着多奈哌齐杂质的形成而降低。

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