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Anti-human PD-L1 humanized monoclonal antibody and application thereof

机译:抗人PD-L1人源化单克隆抗体及其应用

摘要

The present invention relates to the biomedicine field, in particular to an anti-human PD-L1 humanized monoclonal antibody and its applications. The invention obtains an anti-human PD-L1 humanized monoclonal antibody with good specificity, high affinity and stability by screening, and the antibody can specifically bind to human PD-L1 instead of binding to members of B7 family, and it can bind to active T-cells to strengthen the activation of T-cells, so it can significantly inhibit the growth of tumor.
机译:生物医学领域本发明涉及生物医学领域,尤其涉及抗人PD-L1人源化单克隆抗体及其应用。 本发明通过筛选获得具有良好特异性,高亲和力和稳定性的抗人Pd-L1人源化单克隆抗体,并且抗体可以特异性结合人Pd-L1,而不是与B7家族成员结合,并且可以结合活性 T细胞加强T细胞的活化,因此可以显着抑制肿瘤的生长。

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