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Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)
Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)
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机译:结构直肠地图集变形特征,用于在磁共振成像(MRI)中的壁外壁和围壁校准响应
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摘要
Embodiments discussed herein facilitate determination of responsiveness to chemoradiation treatment in rectal cancer patients based on structural deformation features obtained from a pre- or post-treatment medical imaging. One example embodiment can perform operations comprising: accessing an image volume of a rectum comprising a rectal tumor; generating a forward mapping based on non-rigidly registering a healthy rectal atlas to the image volume; inverting the forward mapping to generate an inverse mapping from the image volume to the healthy rectal atlas; determining, based on the inverse mapping, an associated deformation magnitude for each voxel of a plurality of voxels associated with the rectum; computing one or more structural deformation features based on the associated deformation magnitudes for the plurality of voxels; and predicting via a classifier whether or not the rectal tumor will respond to the chemoradiation treatment based at least in part on the one or more structural deformation features.
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