A METHOD FOR DEPLETION OR REMOVAL OF ENDOTOXIN FROM AN ENDOTOXIN-CONTAINING SOURCE OR POTENTIALLY ENDOTOXIN-CONTAINING SOURCE

摘要

A method for depletion or removal of endotoxins from a known or suspected endotoxin-containing source by virtue of a solid phase extraction material in an essentially aqueous system comprising the steps of - providing a known or suspected endotoxin-containing source, - contacting the known or suspected endotoxin-containing source with a positively charged solid phase material having a surface on which ferric iron is immobilised, wherein the solid phase extraction material has immobilised the ferric iron by (2-aminoethyl)amine (TREN) ligand - incubating the known or suspected endotoxin-containing source for a period of time sufficient to bind endotoxin to the porous solid phase material, - separating the solid phase material from the essentially aqueous system, - optionally isolating the essentially aqueous system freed or depleted from endotoxin.