Use of (+) -2-borneol in the preparation of drugs that promote upregulation of sphingosine kinase-1 and / or BDNF expression

摘要

The present invention discloses the use of (+)-2-borneol in the preparation of a medicament for promoting the up-regulation of sphingosine kinase-1 and / or BDNF (brain-derived neurotrophic factor) expression. +)-2-Borneol can be used in the preparation of a medicament that promotes the up-regulation of sphingosine kinase-1 and / or brain-derived neurotrophic factor expression, wherein the medicament comprises astrocyte diffusion and migration, oligodendrocytes Can induce site differentiation and survival, neurite growth and nerve regeneration, and promote up-regulation of brain-derived neurotrophic factor expression, promote neuronal survival and axon growth, infarct volume In addition to suppressing the expansion of the infarct area, preventing the infarct area from further expanding and realizing the effect of directly repairing the damage at the injured area, Thoroughly solve the wound, significantly improves the long-term therapeutic effect.