The present invention relates to trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl for use in the treatment of the primary negative symptoms of schizophrenia and/or the predominant negative symptoms of schizophrenia. ]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine (cariprazine) and pharmaceutically acceptable salts and hydrates and solvates and polymorphs thereof.
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