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OPEN-LOOP/CLOSED-LOOP PROCESS CONTROL ON THE BASIS OF A SPECTROSCOPIC DETERMINATION OF UNDETERMINED SUBSTANCE CONCENTRATIONS
OPEN-LOOP/CLOSED-LOOP PROCESS CONTROL ON THE BASIS OF A SPECTROSCOPIC DETERMINATION OF UNDETERMINED SUBSTANCE CONCENTRATIONS
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机译:开环/闭环过程控制基于一个未确定的物质浓度的光谱测定
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摘要
The invention relates to a method for the open-loop or closed-loop control of a process (3), more particularly a downstream bioprocess, on the basis of the prediction of an unknown concentration of at least one substance in a sample (5a, 5b) by means of spectroscopy, more particularly UV-vis spectroscopy, comprising the steps of: capturing (101) spectra (1) of a plurality of concentration samples, at least two concentration samples having different concentrations of the substance; generating (102) a plurality of quantitative models (M) on the basis of the spectra of the concentration samples, the models (M) each comprising an association between at least one spectral measurement variable (2) of the spectra (1) and concentrations in concentration ranges, the concentration ranges of two models (M) being non-identical; capturing (103) at least one sample spectrum (1; 1a, 1b) of the sample (5a, 5b); assigning (104) the sample spectrum (1; 1a, 1b) to at least one quantitative model (M) of the generated quantitative models (M); applying (105) the at least one quantitative model (M) assigned to the sample spectrum (1; 1a, 1b) to the sample spectrum (1; 1a, 1b) in order to determine a prediction value for the undetermined concentration; and open-loop and/or closed-loop control (108) of the process (3) with respect to at least one parameter on the basis of the prediction value for the undetermined concentration.
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