Operated hematopoietic stem cells for treatment of acute myeloid leukemia

摘要

In one aspect, an operated hematopoietic stem cell comprising a heterologous expression cassette is provided.In some embodiments, the expression cassette is α－ A promoter that is operatively linked to a polynucleotide encoding a hydroxylase protein, including α－ The hydroxylase protein is a human cytochrome P450 family 27 subfamily B member 1 (CYP27B1).