The present invention relates to a biomarker composition for predicting the prognosis of cancer malignancy induced by exposure to microplastics and their use, and more particularly, to a cancer cell line treated with polystyrene microspheres, a type of microplastic, for 4 weeks, and CD44 in an animal model. , E-cadherin, N-cadherin, PD-L1, NPAS2, NR1D1, DNMT1, SLC7A2, PCDH7 and CLDN7 expression level changes were confirmed, and the proliferation, migration and invasion of cancer cells by the change in the expression level of the genes As it was confirmed that malignancy was induced according to the increase and the 5-year overall survival rate of gastric cancer patients decreased, the genes may be provided as a biomarker composition for predicting the prognosis of cancer malignancy by exposure to microplastics.
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