Disclosed are methods, systems, and computer-readable medium to perform operations including performing, using a nanoscale model (202), a simulation of fluid-fluid and fluid-rock interactions in the subterranean formation (204). The operations also include upscaling first results of the simulation of fluid-fluid and fluid-rock interactions to a microscale level (206). The operations further include performing, using a microscale model and the upscaled first results, a simulation of fluid flow inside rocks (208) of the subterranean formation. Additionally, the operations include upscaling second results of the simulation of fluid flow inside rocks to a macroscale level (210). Further, the operations include performing, using a core- scale model and the upscaled second results, a simulation of fluid flow across the subterranean formation.
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