Fusion proteins comprising anti-mesothelin antibodies, anti-CD3 antibodies or anti-EGFR antibodies and bispecific or trispecific antibodies comprising same and uses thereof

摘要

The present invention provides a fusion protein comprising a fragment of an anti-mesothelin antibody, an anti-CD3 antibody or an anti-EGFR antibody and a bispecific antibody specific for mesothelin and CD3 and a trispecific antibody specific for mesothelin, CD3 and EGFR To an antibody and its use, the bispecific or trispecific antibody according to the present invention can be prepared in high yield and purity, and has excellent tumor killing and growth inhibitory effects, so it can be usefully utilized in cancer treatment .