PNEUMOCOCCAL POLYSACCHARIDES AND THEIR APPLICATION IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN-CARRIER

摘要

The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these N serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.