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METHODS AND COMPOSITIONS FOR REDUCING NUMBERS OR ELIMINATING HIV-INFECTED CELLS
METHODS AND COMPOSITIONS FOR REDUCING NUMBERS OR ELIMINATING HIV-INFECTED CELLS
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机译:用于还原数量或消除艾滋病毒感染细胞的方法和组合物
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摘要
A method of reducing or inhibiting migration of HIV-infected CD4+ T cells to tissues comprises contacting the infected cells with a ligand that prevents or inhibits the interaction between a T cell-surface fucosylated glycan and its glycan-binding protein or with a molecule that metabolically inhibits glycosylation or fucosylation in said cell. In vitro and in vivo methods are described. Also described is a diagnostic method employing labeled ligands that bind a fucosylated glycan and provide a signal detectable by non- invasive imaging.
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