Novel bispecific antibody molecules and bispecific antibodies that bind PD-L1 and LAG-3 simultaneously

摘要

the present invention Polypeptide chain of formula (I): VH-CH1-Fc-X-VHH; and Polypeptide chain of formula (II): VL-CL; here: wherein VH represents a heavy chain variable region; CH represents the heavy chain constant region; said Fc comprises CH2, CH3 and optionally CH4; wherein CH1, CH2, CH3 and CH4 represent domains 1, 2, 3 and 4 of the heavy chain constant region, respectively; wherein X is absent or when present represents a linker such as a flexible linker; said VHH represents a single domain antigen binding site, such as a single domain antibody; said VL represents the light chain variable region; CL represents the light chain constant region; Optionally, a hinge region exists between the CH1 and the Fc, and provides a novel artificially designed antibody molecule.