PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity

机译：PD-L1 / LAG-3双特异性抗体增强了肿瘤特异性免疫力

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Haiping Jiang; Haiqing Ni; Pan Zhang; Xiaoli Guo; Min Wu; Haoran Shen; Jie Wang; Weiwei Wu; Zhihai Wu; Jiazheng Ding; Rong Tang; Shuaixiang Zhou; Bingliang Chen; Michael Yu; Hua Jing; Junjian Liu;
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1. 715?FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, induces LAG-3 shedding resulting in receptor downregulation by T cells via a novel mechanism of action [J] . Michelle Morrow, Mustapha Faroudi, Krishnendu Chakraborty, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：715？FS118，靶向LAG-3和PD-L1的四价双特异性抗体，诱导滞后-3脱落，导致受T细胞通过新的作用机制下调的受体
2. FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity [J] . Kraman Matthew, Faroudi Mustapha, Allen Natalie L., Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第13期

机译：FS118，靶向LAG-3和PD-L1的双特异性抗体增强了T细胞活化，导致有效的抗肿瘤活性
3. 395?A first-in-human study of FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, in patients with advanced cancer and resistance to PD-(L)1 therapy [J] . Timothy Yap, Deborah Wong, Siwen Hu-Lieskovan, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：395？在晚期癌症和PD-（L）1治疗的患者中，FS118的首次研究FS118，四价双特异性抗体靶向LAG-3和PD-L1，对PD-（L）1治疗
4. Molecular dynamics of the immune checkpoint Programmed Cell Death Protein I, PD-1: Conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab [C] . Bernhard Roither, Chris Oostenbrink, Wolfgang Schreiner IEEE International Conference on Bioinformatics and Biomedicine . 2019

机译：免疫检查点的分子动力学程序性细胞死亡蛋白I，PD-1：配体PD-L1与单克隆抗体nivolumab结合后BC环的构象变化
5. Development of a novel antibody molecule for redirected T cell immunity to tumor cells: The bispecific single chain antibody [D] . Gruber, Meegan Minori 1996

机译：用于重定向T细胞对肿瘤细胞免疫的新型抗体分子的开发：双特异性单链抗体
6. PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity [O] . Haiping Jiang, Haiqing Ni, Pan Zhang, 2021

机译：PD-L1 / LAG-3双特异性抗体增强了肿瘤特异性免疫力
7. FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity [O] . Matthew Kraman, Mustapha Faroudi, Natalie L. Allen, 2020

机译：FS118，靶向LAG-3和PD-L1的双特异性抗体增强了T细胞活化，导致有效的抗肿瘤活性

PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity

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