Derivatives of 1- (4-isoxazol-5-yl) -1H-pyrazol-1-yl) -2-methylpropan-2-ola and related compounds as inhibitors of IL-17 and IFN-gamma for the treatment of autoimmune and chronic diseases

摘要

The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure (formula (II)), wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trilluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.