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Modified ebolavirus glycoproteins comprising mutations in the head and base domains that increase antibody cross-reactivity
Modified ebolavirus glycoproteins comprising mutations in the head and base domains that increase antibody cross-reactivity
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机译:修饰的eBolavirus糖蛋白,包括头部和基座中的突变,其增加抗体交叉反应性
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摘要
Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
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