Microfluidic model of the blood-brain barrier

摘要

PROBLEM TO BE SOLVED: To provide a culture of brain endothelial cells in a fluid device, and optionally astrocytes and neurons, under conditions in which the cells mimic the structure and function of the blood-brain barrier. Culturing such cells in a microfluidic device, whether alone or in combination with other cells, drives further maturation and / or differentiation over existing systems. In one embodiment, the microfluidic chip comprises two microchannels separated by a porous membrane having a first and second surface, and the neuron is cultured on the first or second surface. NS. [Selection diagram] None