MUTANT AND GENETICALLY MODIFIED FILAMENTOUS FUNGAL STRAINS COMPRISING ENHANCED PROTEIN PRODUCTIVITY PHENOTYPES AND METHODS THEREOF

摘要

The present strains and methods of the disclosure relate to genetic modifications in filamentous fungi that give rise to variant strains of filamentous fungi comprising enhanced protein productivity phenotypes. More specifically, as presented, described and exemplified herein, such variant strains of filamentous fungi comprising enhanced protein productivity phenotypes are well-suited for growth in submerged cultures, such as in large-scale production of proteins of interest for commercial applications.