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SEROTONIN TRANSPORTER GENE AND TREATMENT OF OPIOID-RELATED DISORDERS
SEROTONIN TRANSPORTER GENE AND TREATMENT OF OPIOID-RELATED DISORDERS
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机译:血清素转运蛋白基因和阿片类药物相关疾病的治疗
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摘要
The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
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机译:负责编码SERT的基因在5'-调节启动子区具有功能多态性,其导致两种形式,长(L)和短(S)。 LL-基因型被假设,以在早期的酒精使用中发挥关键作用。 本发明公开了基于L或短基因型的治疗和诊断的差异以及SERT基因的单个核苷酸多态性,3'UTR SNP RS1042173。 本发明证明了使用药物ondansetron和类似药物的疗效基于SERT基因多态性的变化以及用于诊断滥用酒精和其他与其他有关的疾病和疾病的方法的方法。
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