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Serotonin transporter gene and treatment of opioid-related disorders
Serotonin transporter gene and treatment of opioid-related disorders
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机译:血清素转运蛋白基因与阿片相关疾病的治疗
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摘要
The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
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机译:负责编码SERT的基因在5'调控启动子区域具有功能性多态性,导致长(L)和短(S)两种形式。据推测,LL基因型在早期饮酒中起关键作用。本发明公开了基于L或短基因型以及基于SERT基因的3'UTR SNP rs1042173的单核苷酸多态性的治疗和诊断的差异。本发明证明了基于SERT基因的多态性的变化使用药物恩丹西酮和类似药物进行治疗的功效,以及诊断对滥用酒精和其他成瘾相关疾病和病症的易感性的方法。
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