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A FRET-BASED METHOD TO MEASURE SEEDING ACTIVITY OF MISFOLDED PROTEIN SPECIES IN BIOLOGICAL SAMPLES
A FRET-BASED METHOD TO MEASURE SEEDING ACTIVITY OF MISFOLDED PROTEIN SPECIES IN BIOLOGICAL SAMPLES
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机译:一种基于FRET的方法测量生物样品中错误折叠蛋白质种类的播种活性
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摘要
The present invention relates to a method for the quantification of seeding (Δt50) of an amyloidogenic aggregate, methods for assessing the risk for development, predicting the onset or assessing the progression of a polyQ disease, and a method for identifying compounds that inhibit mHTT seeding activity (HSA) in vitro. Further, uses of fluorophore-bearing polyQ proteins, particularly mutant N-terminal huntingtin fragments comprising exon-1 and related soluble protein constructs are provided.
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