Diverse antigen-binding domains for cell therapy, new platforms and other enhancements

摘要

The present disclosure includes a variety of antigen-binding domains and platforms for the construction of conventional and next-generation chimeric antigen receptors for adoptive cell therapy for cancer, infection, allergic, degenerative and immune disorders, as well as. It provides an approach for the activation and amplification of immune T cells for adoptive cell therapy for infection, allergy, degeneration and immune disorders.