Lubricin localized cartilage-like tissue, a method for producing the same, and a composition for treating articular cartilage injury containing the same.

摘要

The present invention is the first center of gravity of a cartilage-like tissue derived from pluripotent stem cells, or the center of gravity which is the inner region of a concentric sphere having a diameter of the first longest diameter × 0.2 centered on the first center of gravity. In an arbitrary cross section passing through the region, in a region inside a concentric circle having a diameter of the longest diameter (second longest diameter) × 0.4 to 0.9 of the cross section centered on the second center of gravity which is the center of gravity of the cross section. The ratio of the amount of rubricin expressed per unit area (central rubricin amount) contained in a certain central region to the amount of rubricin expressed per unit area contained in the non-central region (amount of non-central rubricin) is the amount of non-central rubricin / center. Provided are a rubricin-localized cartilage-like tissue, characterized in that the amount of rubricin is> 1 and localized rubricin, and a method for producing the same. Further provided is a composition for treating articular cartilage injury containing lubricin-localized cartilage-like tissue.