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BIOMARKERS FOR PREDICTING THE RESPONSE TO CHECKPOINT INHIBITORS
BIOMARKERS FOR PREDICTING THE RESPONSE TO CHECKPOINT INHIBITORS
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机译:用于预测对检查点抑制剂的反应的生物标志物
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摘要
The invention provides biomarkers for predicting the response to checkpoint inhibitors. The inventors demonstrate that a PD-1/PD-L1 inhibitor exerts antitumor activity against tumor with low PD-L1 expression and immune-desert phenotype through blocking PD-L1 in the lymph nodes. The invention provides novel combinations of intratumoral markers for antigen cross-presenting cells and T cell chemokines which are expected to be superior efficacy-predicting biomarkers compared to existing methods.
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