DRUG DELIVERY DEVICES HAVING ADSORBED MEDICATION ADHERENCE MARKERS THEREON, PACKAGING INCLUDING THE SAME AND METHODS OF FORMING THE SAME

摘要

Provided herein are pharmaceutical packages that include a pharmaceutical tablet or capsule, and a volatile medication adherence marker (MAM) contained on or in a MAM reservoir external to the pharmaceutical tablet or capsule. Also provided herein are methods of surface coating a pharmaceutical tablet or capsule with a volatile medication adherence marker (MAM) that include placing the pharmaceutical tablet or capsule in a sealed container with the volatile MAM contained on or in a MAM reservoir external to the pharmaceutical tablet or capsule, and maintaining the seal of the container for a sufficient time to allow MAM vapors from the volatile MAM reservoir to adsorb to onto a surface of the pharmaceutical tablet or capsule. Also provided are methods of medication adherence monitoring using such pharmaceutical tablets or capsules.