Bispecific and trispecific functional molecules of ACE2 and complement pathways and their use

摘要

Disclosed herein are ACE2 fusion proteins that can be used to block infection of cells by SARS-CoV-2. The fusion proteins may have additional functionality such as inhibition of complement. The fusion protein may also include a polypeptide or a moiety that increases serum or blood half-life of the ACE2 fusion protein.