BIS1,2,4TRIAZOLO4,3-b:3',4'-f1,2,4,5TETRAZINES WITH ANTI-GLYCATING, ANTI-GLYCOXIDATION AND ANTIPLATELET ACTIVITY

摘要

FIELD: medicine. ;SUBSTANCE: invention relates to derivatives of a new heterocyclic system: 1,8-diarylbis[1,2,4]triazolo[4,3-b:3',4'-f][1,2,4,5]tetrazines of the general formula IIa-c, which have anti-glycating, anti-glycoxidation and antiplatelet activities. ;EFFECT: provided is ability to block the formation of glycation end products and pathological consequences of this process. ;1 cl, 4 tbl, 7 ex