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COMPOSITION FOR INDUCING APOPTOSIS OF CELLS HAVING GENOMIC SEQUENCE VARIATION AND METHOD FOR INDUCING APOPTOSIS OF CELLS BY USING COMPOSITION

机译:用组合物诱导具有基因组序列变化的细胞凋亡的组合物及其通过使用组成诱导细胞凋亡的方法

摘要

The present invention relates to at least one delivery vehicle, a composition comprising the at least one delivery vehicle, and a method for inducing the apoptosis of cells having genomic sequence variation by using the at least one delivery vehicle or the composition, the at least one delivery vehicle comprising: a plurality of cleavage agents or a polynucleotide encoding same, the cleavage agents specifically recognizing a plurality of nucleic acid sequences comprising a unique sequence that is not present in normal cells, from among variation region sequences specific to cells having genomic sequence variation in cells having genomic sequence variation; and a nuclease or a polynucleotide encoding same.
机译:本发明涉及至少一种递送载体,包含至少一种递送载体的组合物,以及通过使用至少一种输送载体或组合物,至少一个诱导具有基因组序列变化的细胞凋亡的方法 递送载体包括:多种裂解剂或多核苷酸编码,细分剂特异性识别多种核酸序列,所述多种核酸序列包含在具有基因组序列变异的细胞特异的变异区段序列中的唯一细胞中不存在的独特序列 在具有基因组序列变异的细胞中; 和核酸酶或编码相同的多核苷酸。

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