METHOD FOR TREATMENT AND PROPHYLAXIS OF CRS IN PATIENTS COMPRISING A COMBINATION OF BISPECIFC ANTIBODIES BINDING TO CDS X CANCER CELL AND TNFALPHA OR IL-6 INHIBITOR

摘要

The present invention relates to medical combination products comprising (i) at least one antibody construct comprising at least one domain which binds to a target antigen expressed on the surface of a cell and at least one other domain which binds to CD3 as well as (ii) at least one molecule that is inhibitor / antagonist of TNF/ TNFR reducing TNF/TNFR signaling and/or an inhibitor / antagonist of IL6/IL6R that reduces IL6/IL6R signaling, wherein a first dose of said inhibitor / antagonist is administered before administration of a first dose of said antibody construct. Furthermore, the invention provides therapeutic and preventive methods and medical uses of said combination products, as well as a kit comprising said at least one antibody construct and at least one antagonist / inhibitor of TNF or IL6 or its cognate receptor, wherein the interaction of said antagonist / inhibitor of TNF or an inhibitor / antagonist of IL6 with its cognate receptor reduces, mitigates, prevents, or treats cytokine release syndrome.