Inhibition of FKBP1A for the therapy of triple-negative breast cancer

摘要

The invention relates to a method for finding inhibitors of the peptidyl-prolyl cis-trans isomerase FKBP1A or of antibodies, proteins or molecules with a specific affinity for FKBP1A. The invention also relates to FKBP1A-specific siRNA, inhibitors of the expression of FKBP1A, inhibitors of the enzymatic activity of FKBP1A, and inhibitors of the interaction (s) of FKBP1A with interaction partner (s) in each case for the treatment of diseases, in particular cancer or neurodegenerative diseases. In addition, the invention relates to the use of FKBP1A as a prognostic or diagnostic marker of cancer diseases. The cancers are preferably breast cancer, in particular triple-negative breast cancer.