首页>
外国专利>
RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES
RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES
展开▼
机译:免疫原性癌症特异性表位的排名系统
展开▼
页面导航
摘要
著录项
相似文献
摘要
This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.
展开▼