Protection of biological active molecules during radiation sterilization

摘要

Compositions and methods relating to protecting biological activity of biological active molecules, including biological response modifiers, such as biological active proteins or immune response modifiers, are disclosed from radiation disorders during radiation sterilization.Spray spray on the surface of the immunoassay tubeFor an exemplary mitogenic hormone formulationAt least one radiation protective compoundFor example:CysteineGlutathione reductaseMelatoninBy including and / or histidineSurprisinglyFrom the biological (mitogen) activity loss that would result from electron beam radiation sterilizationThe lectin was protected.Radiation protective compounds also protect other biological active molecules, stabilize their biological activity, and allow them to retain biological activity after long-term storage after radiation treatment.